V Michael Holers Selected Research

Complement C3 (C3 Complement)

1/2023	Noninvasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent Imaging Probe.
1/2018	The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis.
3/2016	Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.
5/2014	Deficiency of complement receptors CR2/CR1 in Cr2⁻/⁻ mice reduces the extent of secondary brain damage after closed head injury.
12/2007	A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.
5/2006	Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.
3/2003	Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

V Michael Holers Research Topics

Disease

78	Rheumatoid Arthritis 02/2024 - 02/2002
49	Arthritis (Polyarthritis) 11/2023 - 02/2002
46	Inflammation (Inflammations) 11/2023 - 11/2003
16	Autoimmune Diseases (Autoimmune Disease) 08/2023 - 01/2003
11	Experimental Arthritis 09/2023 - 11/2002
11	Ischemia 01/2021 - 07/2001
9	Infections 02/2024 - 09/2005
9	Reperfusion Injury 01/2021 - 07/2001
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2024 - 04/2019
6	Acute Kidney Injury (Acute Renal Failure) 12/2022 - 01/2001
6	Macular Degeneration (Age-Related Maculopathy) 01/2022 - 06/2009
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 04/2019 - 09/2004
6	Lupus Nephritis 05/2010 - 04/2002
5	Osteoarthritis 04/2024 - 11/2011
5	Proteinuria 02/2024 - 10/2003
4	Chronic Disease (Chronic Diseases) 02/2024 - 07/2013
4	Craniocerebral Trauma (Head Injury) 03/2016 - 06/2006
4	Albuminuria 09/2015 - 04/2002
4	Choroidal Neovascularization 05/2013 - 03/2011
4	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2013 - 06/2008
4	Respiratory Hypersensitivity 01/2012 - 12/2003
4	Renal Insufficiency (Renal Failure) 08/2007 - 01/2001
3	Dysbiosis 09/2023 - 01/2018
3	Glomerulonephritis 01/2023 - 04/2004
3	Synovitis 01/2023 - 03/2007
3	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2021 - 05/2009
3	Lung Diseases (Lung Disease) 01/2020 - 05/2009
3	Arthralgia (Joint Pain) 11/2018 - 09/2015
3	Neoplasms (Cancer) 07/2017 - 07/2004
3	Cardiovascular Diseases (Cardiovascular Disease) 07/2017 - 11/2014
3	Pre-Eclampsia (Preeclampsia) 02/2016 - 04/2008
3	Joint Diseases (Joint Disease) 06/2015 - 12/2009
3	Thrombotic Microangiopathies 12/2014 - 12/2009
3	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2014 - 06/2006
3	Neuroinflammatory Diseases 05/2014 - 06/2006
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2005 - 01/2002
2	Anterior Cruciate Ligament Injuries 04/2024 - 01/2023
2	Kidney Diseases (Kidney Disease) 10/2023 - 01/2018
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2022 - 01/2020
2	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 01/2018 - 05/2007
2	Lung Injury 01/2018 - 03/2012

Drug/Important Bio-Agent (IBA)

96	Complement System Proteins (Complement)IBA 04/2024 - 01/2001
49	Proteins (Proteins, Gene)FDA Link 02/2024 - 04/2002
43	AutoantibodiesIBA 11/2023 - 01/2004
28	AntibodiesIBA 11/2023 - 01/2001
25	Anti-Citrullinated Protein AntibodiesIBA 02/2024 - 01/2005
21	CollagenIBA 12/2021 - 08/2006
14	AntigensIBA 11/2023 - 03/2007
14	Biomarkers (Surrogate Marker)IBA 09/2023 - 04/2008
13	Rheumatoid FactorIBA 09/2022 - 01/2005
12	Immunoglobulin M (IgM)IBA 10/2021 - 01/2007
12	CytokinesIBA 01/2021 - 07/2006
11	Immunoglobulin G (IgG)IBA 11/2023 - 11/2003
11	EpitopesIBA 01/2023 - 02/2008
10	cyclic citrullinated peptideIBA 01/2023 - 01/2005
10	Complement Receptors (Complement Receptor)IBA 01/2020 - 10/2002
10	Complement Inactivating AgentsIBA 01/2020 - 01/2001
9	Complement Factor B (Factor B)IBA 07/2013 - 01/2005
8	Complement Factor H (Factor H)IBA 01/2018 - 11/2009
8	Complement 3d Receptors (Complement Receptor 2)IBA 05/2014 - 12/2004
7	Complement C3 (C3 Complement)IBA 01/2023 - 03/2003
7	Antigen-Antibody Complex (Immune Complex)IBA 06/2013 - 01/2003
6	Immunoglobulin A (IgA)IBA 11/2023 - 09/2013
6	acetyl 4-aminosalicylic acidIBA 01/2023 - 08/2013
6	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020 - 12/2004
6	LectinsIBA 01/2020 - 08/2006
6	Monoclonal AntibodiesIBA 07/2013 - 03/2006
5	Peptides (Polypeptides)IBA 01/2021 - 12/2003
5	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 09/2018 - 11/2010
4	EnzymesIBA 01/2021 - 01/2004
4	AutoantigensIBA 01/2021 - 01/2003
4	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 02/2002
4	Mannose-Binding Protein-Associated Serine Proteases (Mannose-Binding Protein-Associated Serine Protease)IBA 01/2017 - 11/2010
4	Complement C3-C5 Convertases (C3 Convertase)IBA 05/2014 - 08/2003
3	Insulin (Novolin)FDA Link 02/2024 - 07/2023
3	RNA (Ribonucleic Acid)IBA 11/2023 - 01/2019
3	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2023 - 08/2007
3	Complement C3b (C3bi)IBA 01/2023 - 09/2005
3	Messenger RNA (mRNA)IBA 01/2022 - 08/2006
3	Complement Factor D (Factor D)IBA 01/2020 - 11/2016
3	AlbuminsIBA 01/2020 - 04/2002
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 12/2017 - 02/2016
3	Collagen Type II (Type II Collagen)IBA 02/2015 - 08/2006
3	ChemokinesIBA 11/2014 - 11/2010
3	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 03/2005
3	AllergensIBA 01/2012 - 12/2003
3	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 11/2011 - 01/2001
2	Antirheumatic Agents (DMARD)IBA 10/2023 - 09/2015
2	Methotrexate (Mexate)FDA LinkGeneric 10/2023 - 01/2021
2	complement C3d,gIBA 01/2021 - 09/2005
2	Blood Proteins (Serum Proteins)IBA 01/2020 - 04/2016
2	Aquaporin 4IBA 01/2019 - 11/2003
2	Serine (L-Serine)FDA Link 09/2018 - 01/2017
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2018 - 03/2012
2	CreatinineIBA 01/2018 - 04/2002
2	Collagen Type VIIIBA 01/2018 - 05/2007
2	LigandsIBA 01/2017 - 05/2013
2	Serine Proteases (Serine Protease)IBA 11/2016 - 11/2010

Therapy/Procedure

11	Therapeutics 10/2023 - 12/2003
4	Lasers (Laser) 06/2013 - 03/2011